Abstracts

University of Missouri

Biological Modeling Software

Jianlin Cheng’s lab is a world leader in creating software and algorithms that predict biological structure and function based on sequences. His protein structure prediction tool MULTICOM was recognized as one of the top three predictors at a reputed international conference in 2014, and that prediction tool forms the foundation for 3-D genome structure modeling and biological network modeling.
3-D Genome Structure modeling software, called MOGEN, can handle both inter-chromosomal and intra-chromosomal interaction data to build the structure of the entire genome consisting of a number of chromosomes. Most methods in the field can only deal with intra-chromosomal interaction data to build the structure of individual chromosomes. This software has major applications in drug discovery and precision medicine.

Biological Network Modeling software, called GNET, is one of the few tools that can integrate big transcriptomics data and genomics data to automatically build reliable gene regulatory networks and key transcription factors that can generate valuable hypotheses for biomedical experiments.

Potential Areas of Application
  • Precision medicine
  • Drug discovery
  • Agriculture and crop development
Patent Status

Patent pending

Inventor(s)

Jianlin Cheng

Contact Info

Brett Maland, 573-882-1046 or malandb@missouri.edu

Hands-Free Communication System in Mass Casualty Disaster Triage Over a Stand-Alone Wi-FI Network

This invention consists of a system that allows multiple users in a mass-casualty disaster field triage scenario to communicate with each other and a central incident commander using hands-free devices and location beacons. The network can be deployed quickly and is independent of infrastructure, which may be compromised after such a disaster. It can also work with existing infrastructure that may be present to boost performance.

Medical staff having their hands free to diagnose and treat patients in a mass casualty situation can greatly increase the survival rate of patients. It may also reduce the spread of infections in a disaster because the responders will not have to continue touching common items such as clipboards and pens.

Potential Areas of Application
  • Triaging mass-casualty emergencies
Patent Status

Patent pending

Inventor(s)

Salman Ahmad, John Gillis, Calyam Prasad and Mihail Popescu

Contact Info

Brett Maland, malandb@missouri.edu or 573-882-1046

Knee Joint Angle Measurement for Injury Prevention

Anterior cruciate ligament (ACL) knee injuries occur four to six times more often in females than males. ACL rupture leads to costs between $17,000 to $25,000 for surgery and rehabilitation per patient, and nine to 12 months of missed participation in sports. An estimated 38,000 ACL injuries in girls and women in 2001 cost roughly $650 to $950 million to treat. There are several recognized biomechanical and neuro-muscular abnormalities that have been shown to increase the risk of ACL rupture in females, compared to males. If identified early through appropriate screening tests, aberrant jumping and landing patterns can be corrected with specific ACL injury prevention programs, leading to a relative risk reduction of 30 to 80 percent. These biomechanical and neuromuscular abnormalities are a modifiable risk factor, correctable by focused strengthening programs and neuromuscular re-education.

The gold standard of measurement of these high-risk knee angles during a landing and jumping task uses multiple high speed cameras that track reflective markers placed on a test subject. A standard system is laboratory based and costs over $100,000 to install. MU researchers have a portable, inexpensive system (<$300) that can measure individuals much more quickly and efficiently than previous technology. This provides the opportunity for an instantaneous ACL injury risk assessment profile for the subject. Potential venues for ACL injury screening include orthopedic clinics, physical therapy units, public and private gyms and during school pre-participation annual physical examinations. This technology also can be used to create software and video games that use this device for immediate biofeedback to teach proper movement and exercise techniques.

Potential Areas of Application
  • Immediate biofeedback for improving neuromuscular control
  • Identify female athletes at high risk for ACL injury
Intellectual Property Status

Copyright

Inventor(s)

Aaron Gray and Marge Skubic

Contact Info

Brett Maland, malandb@missouri.edu or 573-882-1046

Method for Objective Assessment and Training of Medical Diagnostics Skills Based on Whole-Slide Histopathology Imaging and Gaze-Tracking

The present invention comprises software designed to teach objective assessment and training of medical diagnostic skills by simulating real-life scenarios more accurately than any other training system. The invention is an interactive software designed for pathology, which features visual-based, problem-based and incentive-based learning. It includes a database of imaged pathology slides and poses problems to users in the form of interactive case studies, wherein the user, after visualizing a picture, must determine the appropriate diagnosis/clinical test/course of action from a set of given choices. Users are then receive a monetary reward or punishment to simulate real-life, cost-based medical decision-making.

Potential Areas of Application
  • Objective assessment and training of medical diagnostic skills relatedto pathology
Patent Status

Patent pending

Inventor(s)

Dmitriy Shin, Richard Hammer and Donald Doll

Contact Info

Brett Maland, malandb@missouri.edu or 573-882-1046

Quality Improvement Project Tracker

This software is a robust tracking tool based on a new program design that features quality strategy, performance, and systems tracking using the interconnectivity of smartphones and the Internet. The software features accessible project count reports, project charter printouts and financial impact reports.

Potential Areas of Application
  • Construction projects
  • Research projects
Intellectual Property Status

Copyright

Inventor(s)

Koby Clements, Eric Franks, Douglas Wakefield and Kimberli Davis

Contact Info

Brett Maland, malandb@missouri.edu or 573-882-1046

Static and Moving Object Detection Using Flux Tensor With Split Gaussian Models

Flux Tensor With Split Gaussian models (FTSG) is a moving-object detection system with applications in security and in driverless vehicles. This hybrid system can handle challenges such as shadows, illumination changes, dynamic background, stopped and removed objects. FTSG is superior to other moving-object detection methods in handling certain classes of complex background dynamics like water fountains, rippling waves, thermal turbulence and weather conditions such as rain and snow. In other words, FTSG can detect moving objects even with noise that distorts other moving object detection systems. FTSG demonstrates superior performance in low-frame rate videos; nighttime shots; and pan, tilt and zoom (PTZ) camera videos.

Potential Areas of Application
  • Object detection
  • Security cameras
Patent Status

Patent pending

Inventor(s)

Filiz Ersoy, Rui Wang and Kannappan Palaniappan

Contact Info

Brett Maland, malandb@missouri.edu or 573-882-1046

Structure From Motion and Bundle Adjustment for Aerial Imagery and Photogrammetry

MU researchers have created a fast and efficient bundle adjustment pipeline developed for refinement of camera parameters for aerial imagery, such as wide-area motion imagery and photogrammetry. The unique feature of this invention is that it contains a robust function capable of taking the sequentially acquired images and extracting features that are matched only between each two successive frames, while at the same time tracking the corresponding features that are constructed over multiple frames. This can be used for tracking objects as they move through frames and is extremely beneficial for high-pursuit scenarios where traditional technology would have trouble tracking objects as the helicopter moves and the light changes.

Potential Areas of Application
  • Military surveillance
  • Police surveillance
  • UAV photography
  • Movie industry
Patent Status

Patent pending

Inventor(s)

Hadi Ali Akbarpour and Kannappan Palaniappan

Contact Info

Brett Maland, malandb@missouri.edu or 573-882-1046

Tongue Imaging for Determining Health Status

In traditional Chinese medicine, the tongue is an important indicator of overall health. Various areas of the tongue are thought to be associated with bodily functions, and traditional Chinese healers make health recommendations based on viewing the tongue. According to traditional Chinese medicine, a view of different features of the tongue can indicate the health of internal organs such as the kidneys, bladder, intestine, spleen, stomach, liver, gallbladder, lungs and the heart.

MU researchers have developed a computational method that can be used to standardize these diagnoses based on the tongue and have packaged the method with a database of known tongue-health associations into a mobile app that will allow users to have traditional Chinese healing advice at their fingertips. A user of this mobile app can take a picture of his tongue and the code developed at MU will compare that image with a large database of images to indicate the health of the user’s organs. Other users can also monitor changes in their own tongue using this mobile app to obtain even more personalized health information.

Potential Areas of Application
  • Analysis of tongue to detect physical status via use of mobile device
Intellectual Property Status

Copyright

Inventor(s)

Ye Duan, Dong Xu and Shao Li

Contact Info

Brett Maland, malandb@missouri.edu or 573-882-1046

Track the Trends in Complex Data With TREND

Our TREND software conveniently finds the main trends of change between measurements. This avoids time-consuming standard interpretation of complicated data. TREND is suited for interpreting data collected by many kinds of laboratory techniques of imaging, spectroscopy and other analytical techniques. Many potential applications await in imaging modalities in medicine, laboratory imaging and environmental imaging. These applications include reconstructing the images from selected components, providing insight and simplification. In drug discovery, how tightly molecular “hits” bind to drug targets can be quantified faster than before. The time courses of physiological and chemical changes can be determined faster than before. TREND accomplishes all of this using a convenient implementation of the widely trusted technique of principal component analysis. R&D personnel will find TREND provides insight faster and easier.

Potential Areas of Application
  • Medical imaging and research imaging: easily identify key trends (e.g., time-dependent) and group similar images
  • Drug discovery: quantify affinities quickly and conveniently
  • Chemical reactions: quantify time courses easily
Intellectual Property Status

Copyright

Inventor(s)

Steven Van Doren and Jia Xu

Contact Info

Brett Maland, malandb@missouri.edu or 573-882-1046

University of Missouri - St. Louis

Novel Tool to Optimize Resources and Improve Efficiencies in Construction Projects

Across a wide range of industries, from construction to pharmaceuticals, optimizing resource management, supply chain design, and logistics is essential to keep costs low and projects on time. UMSL researchers have developed a novel Resource Distribution Decision Tool for construction projects to significantly improve efficiencies.

Current project management software does not account for exogenous disturbances, but this model takes this into consideration to determine the maximum rate-of-return (ROR) and optimal project makespan. Compared to the traditional Critical Path Method, this new solution improved the ROR by 16 percent and shortens project makespan from 65 days to 59 days.

Construction is one example of many industries that must deal with complex project schedules needing optimal allocation of resources in real time to save time and money. Current solutions on the market lack a dynamic optimization decision support function, which can have a huge impact on finish times and rate-of-return. The new Resource Distribution Tool provides this function.

Potential Areas of Application
  • Construction
  • Pharmaceutical
  • Oil & gas
  • Military applications
  • Supply Chain
  • Logistics
Intellectual Property Status

Copyright

Inventor(s)

Haitao Li and Ceki Halmen

Contact Info

Craig Weilbaecher, weilbaecherc@umsl.edu or 314-516-4248